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許多民眾對於犀利士每日錠躍躍卻試，但往往不知道使用原則及注意事項，現在與大家分享tadalafil的使用事項及併用原則。另外也特別提醒民眾，使用該類藥物必須諮詢專科醫師建議，切勿胡亂服藥。在某種程度上，犀利士哪裡買的發展已超越了很多的同行業務，但其從未停止腳步一直砥礪前行著。 一、犀利士5mg與10mg、20mg的差別？ 大家一定想說，就劑量不同啊，的確如此，但是每天服用5毫克的tadalafil與單次服用5毫克是不一樣的唷。當健康受試者服用之劑量範圍為 2.5 至 20 毫克時，tadalafil 之暴露量(AUC)和劑量呈線性(如下圖)，但是tadalafil的代謝慢、半衰期長(17.5小時)，所以每日服用具有加成性。研究顯示每天服用犀利士每日錠5毫克tadalafil，在 5 天內血漿濃度可達穩定狀態，此時之暴露量約為單一劑量給與藥物後的 1.6 倍，簡單來說相對於單次服用8毫克的劑量。 從下圖可見，單次口服給藥後，最大血漿濃度(Cmax)之時間在給藥後 30 分鐘至 6 小時間(中位數為 2 小時)，所以tadalafil建議至少在事前30分鐘至2個小時服用。倘若每日服用5毫克，血中隨時保持在8毫克相對效益，節省等後藥效發揮的時間。另一方面，從副作用來看，服用劑量愈高，副作用發生比例愈高，所以一般建議從較低劑量補充為宜。 二、犀利士Tadalafil 5毫克使用注意事項 不少民眾一定困擾過，如果每天服用犀利士每日錠，可以在需要時再併用較高單位的錠劑或併用sildenafil嗎？答案是看劑量而定。從tadalafil藥物動力學來看，每天服用5毫克持續5天，血漿濃度可達穩定狀態，此時血中濃度約為8毫克的服用劑量，所以若有需要，仍可於性行為前30分鐘補服用Tadalafil 10毫克。另外有研究顯示，每日服用tadalafil 5毫克情況下，需要時併用50毫克 的sildenafil改善勃起功能效果更佳，且副作用發生率沒有提高，顯示二者需要時併用是安全的。 大家都知道, tadalafil與硝化甘油併用，可能導致血壓明的下降，甚至產生危險，所以禁止併用。但倘若有併用的可能，到底要間隔多久才不會影響血壓呢？藥品仿單明確指出，二者間隔48小時以上，就不太會造成血壓改變。除此之外，另一個常見併用引起血壓降低的是「酒精」，事實上酒精本身就是種輕度的血管擴張劑，如果飲用超過5 單位或更多酒精【註】且併服tadalafil，會增加直立性低血壓病徵與癥狀的發生率，包括心跳加速、站立時血壓降低、頭暈與頭痛等。 一般來說，腎功能嚴重至肌酸酐清除率< 30 mL/min，或有以下心血管疾病的民眾，不建議服用犀利士每日錠。 (1)有最近90天內有心肌梗的病人…
For freight forwarders in Australia, shipping batteries internationally involves a series of procedures and considerations to ensure the safe and compliant transportation of these goods. Here¨s a comprehensive guide to the processes and precautions involved in international battery shipping.with air…
Finding the perfect gift can be challenging, but a snow globe key holder is a thoughtful and charming choice. Combining utility with sentimentality, it offers a unique way to celebrate memories and milestones. Whether you¨re shopping for friends, family, or…